Validation of a Prospective Urinalysis-Based Prediction Model for ICU Resources and Outcome of COVID-19 Disease: A Multicenter Cohort Study

In COVID-19, guidelines recommend a urinalysis on hospital admission as SARS-CoV-2 renal tropism, post-mortem, was associated with disease severity and mortality. Following the hypothesis from our pilot study, we now validate an algorithm harnessing to predict outcome need for ICU resources hospital. Patients were screened urinalysis, serum albumin (SA) antithrombin III activity (AT-III) obtained prospectively admission. The risk unfavorable course categorized (1) “low”, (2) “intermediate” or (3) “high”, depending normal abnormal SA ≥ 2 g/dL AT-III 70%, abnormality. Time death served primary endpoint. Among 223 patients, 145 eligible enrollment, 43 falling into low, 84 intermediate, 18 high-risk categories. An significantly elevated (63.7% vs. 27.9%; HR 2.6; 95%-CI 1.4 4.9; p = 0.0020) 100% in group. Having mortality, mechanical ventilation, extra-corporeal membrane oxygenation replacement therapy. conclusion, data confirm that COVID-19-associated urine abnormalities aggravation (ClinicalTrials.gov number NCT04347824).